- Cognitive Inflexibility in Eating Disorders Study
- Theta Burst Stimulation (TBS) Study
- Mood and Motivation Study
- LGB Youth and Motivation Study
This study is being conducted to better understand whether the importance of two facets of cognitive inflexibility – attentional set-shifting and reversal learning –are related to differences in eating disorder presentation. Women and men between the ages of 18 and 55 with anorexia nervosa and bulimia nervosa as well as healthy adults are assessed using a battery of behavioral assessments that include interviews, questionnaires, and computer tasks. To examine neural correlates, images of the brain are taken using an MRI scan while the individual completes tasks designed to capture differences in attentional set-shifting and reversal learning. Funding Source: NIMH R01 MH103230
Depression is a chronic, impairing form of psychopathology that is one of the world’s leading causes of disability. Brain connectivity and activity in a region in the prefrontal cortex (the dmPFC) has recently been identified as a biomarker for some types of depression. In addition to this, other studies have shown changes in dmPFC connectivity after transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique that manipulates cortical excitability, in people with depression.
In this study, we will build upon these prior findings to further explore the feasibility of stimulation to alter neural activity and connectivity, using a mix of functional MRI and TMS to examine the acute effects of theta-burst stimulation (TBS) to the dmPFC in 36 young adults with depression (18-25 years). Participation involves 5 trips into the lab and includes an interview, questionnaires, computer tasks, fMRI scans, and theta-burst stimulation.
Anhedonia, or the loss of interest or pleasure in daily life and activities, is a symptom of various mental health disorders such as depression, bipolar disorder, and schizophrenia. We will recruit 145 adolescents, ages 13-17, who have a parent or sibling that has a history of depression, bipolar disorder, or schizophrenia. The participating adolescents will have little to no history of mental health disorders themselves. Analyses will focus on understanding how anhedonia develops in this high-risk sample and how it affects brain function over the course of adolescence. This study will be conducted over approximately 3 years with 1-2 visits per year. These visits include interviews, questionnaires, computer tasks, and an fMRI brain scan each year. Participants will be compensated for their time. IRB: PRO14120041
This study is focused on 16-20 year olds who identify as lesbian, gay, or bisexual or who experience any same-sex attraction. LGB youth are particularly at risk for developing mental health problems over the course of adolescence. Because of this mental health disparity, we think it is especially important to study how this group of people develops. We hope to involve 40 LGB youth in our study to better understand the neural, behavioral, and social correlates of mental health symptoms. We encourage LGB youth with and without mental health disorders to participate. This study involves an fMRI brain scan, an interview, surveys, and computer games. IRB: PRO14120041